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Portinari was intimately connected with Santa Maria Nuova because the hospital was founded by one of his ancestors in Astonishingly, Santa Maria Nuova remains an active hospital to this day and is one of the oldest active hospitals in the world. It is believed to be the hospital where Leonardo da Vinci performed his innovative experimental dissections of human cadavers.
Tommaso Portinari managed the Bruges branch of the Medici bank located in modern Belgium where he had access to artists who were operating outside the direct influence of the Italian Renaissance.
Unlike their Italian counterparts, northern artists used oil paint as their main medium, as opposed to tempera mixtures. Oil paint took longer to dry than tempera, allowing artists to blend their colors more effectively. Moreover, due to its translucent nature, oil paint enables light to penetrate each layer of paint and reflect those layers back to the viewer, similar to what happens when light enters a prism or a diamond.
Because of the profound differences seen in oil paint, the Portinari Altarpiece caused a sensation when it finally arrived in Florence in Indeed, it was to fundamentally change the trajectory of the Italian Renaissance, inspiring famous artists such as Leonardo Da Vinci and Raphael to use oil as their main medium.
In addition to his use of oil paint, Van der Goes was known for his acute attention to detail, complex landscapes, and superb lighting. Northern artists like Van der Goes were also well known for the extensive use of iconography. Indeed, the central panel of the Portinari Altarpiece is rife with symbolism.