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No use, distribution or reproduction is permitted which does not comply with these terms. Chronic inflammatory skin diseases are multifactorial diseases that combine genetic predisposition, environmental triggers, and metabolic disturbances associated with abnormal immune responses.
From an immunological perspective, the better understanding of their physiopathology has demonstrated a large complex network of immune cell subsets and related cytokines that interact with both epidermal and dermal cells. For example, in typeassociated diseases such as alopecia areata, vitiligo, and localized scleroderma, recent evidence suggests the presence of a type-2 inflammation that is well known in atopic dermatitis.
Whether this type-2 immune response has a protective or detrimental impact on the development and chronicity of these diseases remains to be fully elucidated, highlighting the need to better understand its involvement for the management of patients.
This mini-review explores recent insights regarding the potential role of typerelated immunity in alopecia areata, vitiligo, and localized scleroderma. Keywords: type-1 immunity, type-2 immunity, atopic dermatitis, localized scleroderma, alopecia areata, vitiligo. The characterization of the diversity of immune cell subsets has extended our understanding of the complexity of the mechanisms driving the development and recurrence of chronic inflammatory disorders and hastened the subsequent use of targeted therapies.
