Official websites use. Share sensitive information only on official, secure websites. Vesicular stomatitis virus infection causes a rapid and potent inhibition of both host transcription and translation. Recently, the viral matrix M protein was shown to inhibit host-directed transcription in vivo in the absence of any other viral component B.
Black and D. Lyles, J. The goal of this study was to determine the effect of M protein on host-directed translation. On the contrary, this study gave the unexpected result that M protein actually stimulated host-directed translation under the same conditions in which it potently inhibited host-directed transcription. Under these conditions, the combined effect on host gene expression was a greater-thanfold inhibition.
Furthermore, the enhancement of host translation mediated by M protein was genetically correlated with M protein's ability to inhibit host transcription. Thus, the results of this study establish that M protein does not inhibit host protein synthesis under the same conditions in which it potently inhibits host transcription and suggest that the inhibition of transcription and that of translation by vesicular stomatitis virus require separate viral gene products.
These references are in PubMed. This may not be the complete list of references from this article. As a library, NLM provides access to scientific literature. J Virol. Effect of vesicular stomatitis virus matrix protein on host-directed translation in vivo.
Find articles by B L Black. Find articles by G Brewer. Find articles by D S Lyles. PMC Copyright notice. Full text PDF. Previous Next. Image on p. Similar articles. Add to Collections. Create a new collection. Add to an existing collection. Choose a collection Unable to load your collection due to an error Please try again.
