Official websites use. Share sensitive information only on official, secure websites. Yet, some may prefer not to take systemic daily medication. MTN was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse RAI , compared to daily oral tablet. Most partners had no reaction to gel use.
Ease of gel use improved significantly between the first and the last few times of daily use. A rectal gel used before and after RAI may constitute an attractive alternative to daily tablet. Experience with product use may increase acceptability. To some extent, such use hinges on product acceptability, i.
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Several studies have assessed the acceptability of oral PrEP. Although its definition varies among studies, acceptability in general is high [ 1 ] and may be affected by cost [ 2 β 8 ], perceived effectiveness [ 3 β 5 ], potential side effects [ 4 , 5 , 7 ], risk perception [ 1 , 7 β 10 ], dosing regimen i.
Other studies have focused on the acceptability of rectal PrEP to be used in association with receptive anal intercourse RAI. They showed that the acceptability of potential rectal microbicides is affected by product formulation i. However, these findings stem from studies that were either hypothetical participants expressed their opinions without actually using a product , placebo trials the products used did not contain agents that could potentially have microbicide properties or Phase 1 safety trials in small numbers of low-risk participants.
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This manuscript is the first to report in detail the acceptability findings from a Phase 2, expanded safety rectal microbicide trial. It focuses on the acceptability of a rectal microbicide gel used daily or in association with RAI in comparison to the acceptability of daily oral tablet.
