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To browse Academia. Objective: Ultrasound has become a widespread noninvasive method for prenatal screening and diagnosis. In our retrospective study we determined the accuracy of ultrasonography in screening for fetal malformations. Methods: the study was performed over a period of 7 years and we focused our research on major or minor relevant malformations. In most of the cases, the prenatal diagnosis of malformation was established on ultrasound criteria.
Results: the most frequent fetal anomalies detected in our clinic were: chromosomal anomalies trisomy 21 -Down syndrome, trisomy 13 -Patau Syndrome, trisomy 18 -Edwards syndrome, Turner syndrome, cri du chat syndrome ; central nervous system malformations, especially neural tube defect -spina bifida, anencephaly, encephaloceles; cardiovascular malformations; anomalies involving the renal and urinary tract system, the abdominal wall and digestive system, the face and the limbs.
Ultrasound sensitivity for major abnormalities was Conclusions: routine ultrasound examination can achieve a detection rate of congenital anomalies. Apart from the diagnosis of cardiac abnormalities, the Results are satisfactory and justify routine ultrasound screening for malformation. It is expected that ultrasound will continue to improve, and it is hoped that techniques used in the fields of noninvasive prenatal diagnosis will continue to advance.
Objective: To analyze the prenatal ultrasound findings of the craniofacial and extracephalic anatomy, the postnatal pathological findings, and the genetic anomalies in 51 cases of holoprosencephaly HPE. Magnetic resonance MR imaging was performed on two women at the 33rd and 34th pregnancy week, respectively, after ultrasonographic detection of a brain malformation.
Fetal neuromuscular blockade was induced by pancuronium bromide injected into the umbilical vein under continuous ultrasound US guidance. M R images supported the echotomographic diagnosis of holoprosencephaly, improving the image quality and offering additional information in such cases of difficult differential fetal diagnosis.