Official websites use. Share sensitive information only on official, secure websites. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
No use, distribution or reproduction is permitted which does not comply with these terms. All the factors potentially influencing tacrolimus dose requirement and combinations thereof have never been thoroughly investigated, precluding accurate prediction of tacrolimus starting dose.
Statistical analysis employed mixed linear models with repeated measures. Eighteen sites enrolled patients and followed them up for 9. We found no ethnicity effect when CYP3A phenotype was accounted for, and no food effect. Keywords: tacrolimus, pharmacokinetic variability, diet, ethnicity, genetic polymorphisms. Tacrolimus is an immunosuppressant widely used for the prevention of allograft rejection in solid organ transplantation.
However, it is characterized by a narrow therapeutic window and extensive Inter-Individual Variability IIV resulting in a challenging determination of the appropriate dose that is both safe and effective at the individual level [ 1 β 4 ].
Rapid achievement of trough blood levels in the desired target range is critical to optimize safety and efficacy during the early post-transplant period [ 1 ].
