You have full access to this open access article. The essential oils EOs of Eucalyptus camaldulensis , E.
In silico predictive ADMET study was also developed to investigate the pharmacokinetic profile and predict globulol toxicity. This study is a first record for E. Essential oils EOs have a numerous biological activities; anti-parkinson, antifungal, anticarcinogenic, insecticide, anti-inflammatory, antimicrobial, antiviral and antioxidant [ 1 , 2 ]. The interest in EOs has been growing in food, cosmetic, medical, and pharmaceutical fields [ 3 ].
EOs and their pure compounds have been expressed as valuable antiviral drug candidates against RNA and DNA viruses in various host cell lines by blocking different steps of the viral life cycle [ 4 ]. These effects are due to the oil mono- and sesquiterpene hydrocarbons, alcoholic, phenolic, and other oxygenated constituents [ 4 ]. They have been documented against a variety of viruses; avian influenza A virus, human herpes virus, human immunodeficiency virus, Zika virus, and influenza A virus H1N1 [ 5 ].
Allium sativum, Melissa officinalis , Citrus limon, Eugenia brasiliensis , Cedrus libani , Geranium dissectum, Zataria multiflora , Zingiber zerumbet and, Vetiveria zizanoides. EOs together with their derivative compounds have been suggested as potent anti-COVID drugs, which could hinder CoV entry into the human body [ 6 , 7 ]. The symptoms of SARS-CoV-2 have an incubation period of 2 weeks until the signs; cough, fever, lung damage, and dyspnea are expressed [ 8 ]. While studying drug targeting for the optimization of novel SARS-CoV-2 inhibitors, it was noted that the main protease Mpro , as an ideal target for drug development, is responsible for major vital functions including the viral replication processes, with a highly conserved catalytic domain.
Also, angiotensin-converting enzyme-2 ACE2 receptor showed a crucial role in infection through a receptor-mediated interaction. This allows the virus entry into the host cell through the active receptor-binding domain RBD in the spike protein S found on surface of the virus [ 9 ]. Thus, drugs that can inhibit one of these proteins would be identified as potential new anti-COVID compounds [ 9 , 10 ].
