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Fibrosis-4 test FIB-4 is one of the simplest, free of charge, noninvasive scoring tests. We aimed to prospectively measure the prevalence of liver fibrosis in adults with no previously known liver disease and who consulted a general practitioner by FIB-4 score; compare this test to an NAFLD Fibrosis Score NFS and Fibrometer FM ; explore the prevalence of risk factors obesity, diabetes, alcohol, and hypertension and reconsider a possible cause of liver disease in patients recognized as FIBpositive.
Over a 6-month period, 40 general practitioners GPs offered all their consecutive adult primary care patients with no previously known liver pathology and a liver fibrosis screening via a blood test of three scores. The prevalence of significant liver fibrosis by FIB-4, according to age was By comparison, prevalence was Liver fibrosis was suspected by FIB-4 score in The FIB-4 score that can be automatically generated should allow earlier recognition of liver disease in the general population.
Keywords: fibrosis-4 test, general practice, liver fibrosis, noninvasive tests, screening. Liver fibrosis was suspected by FIB-4 score in of A significant relationship was observed between FIB-4 fibrosis risk stages low, intermediate, and high risk and significant fibrosis defined by two other more accurate but more costly scores, namely NAFLD score and Fibrometer.
The FIB-4 score is automatically generated as soon as the transaminases and platelets levels are measured and allows earlier recognition and management of chronic liver disease. Chronic liver disease CLD can lead to a progressive accumulation of fibrosis in the liver which may progress to cirrhosis and hepatocellular carcinoma HCC. The burden of CLD worldwide is substantial, with approximatively 2 million deaths annually attributed to cirrhosis and HCC, caused mainly by nonalcoholic fatty liver disease NAFLD , alcohol-related liver disease, or viral hepatitis, in addition to other important but less common causes of CLD [ 1 β 6 ].
