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Official websites use. Share sensitive information only on official, secure websites. Correspondence: PhesseT cardiff. Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate cancer that can facilitate tumor formation, progression, and therapeutic resistance.
Recent discoveries indicate that targeting the Wnt pathway to treat prostate cancer may be efficacious. However, the functional consequence of activating the Wnt pathway during the different stages of prostate cancer progression remains unclear. Preclinical work investigating the efficacy of targeting Wnt signaling for the treatment of prostate cancer, both in primary and metastatic lesions, and improving our molecular understanding of treatment responses is crucial to identifying effective treatment strategies and biomarkers that help guide treatment decisions and improve patient care.
In this review, we outline the type of genetic alterations that lead to activated Wnt signaling in prostate cancer, highlight the range of laboratory models used to study the role of Wnt genetic drivers in prostate cancer, and discuss new mechanistic insights into how the Wnt cascade facilitates prostate cancer growth, metastasis, and drug resistance.
Prostate cancer is the second most common cancer in men, with global prostate cancer-related deaths exceeding , annually [ 1 ]. Of note, treatment discontinuation in the enzalutamide treatment arm was higher than the standard of care arm in the ENZAMET trial, reflecting adverse side effects e.
However, despite the evolving range of treatment options for mHSPC and mCRPC, disease progression is inevitable, and survival rates remain low as the aggressive cancer cells instigate new molecular mechanisms to evade treatment.