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Official websites use. Share sensitive information only on official, secure websites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls.
The current study sought to evaluate the extent to which HPV16 E6 antibodies are present before diagnosis of anogenital cancers within the same cohort. Four hundred incident anogenital cancers cervical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers with prediagnostic blood samples collected on average 3 and 8 years before diagnosis for cervix and noncervix cancers, respectively and matched controls were included. Plasma was analyzed for antibodies against HPV16 E6 and multiple other HPV proteins and genotypes and evaluated in relation to risk using unconditional logistic regression.
HPV16 E6 seropositivity was present in HPV16 E6 seropositivity was less common for cancers of the cervix 3. HPV16 E6 seropositivity tended to increase in blood samples drawn closer in time to cancer diagnosis.
HPV16 E6 seropositivity is relatively common before diagnosis of anal cancer but rare for other HPV-related anogenital cancers. Previous case-control studies have reported associations between HPV16 E6 seropositivity and anogenital cancers, specifically among cancers of the uterine cervix 13 β 17 and penis 18 ; these studies were retrospective, with blood samples collected at the time of diagnosis.
Three prospective studies on HPV16 E6 seropositivity and anogenital cancer have been conducted to date, two for cervical cancer 19 , 20 and one for anal cancer. We aimed to clarify the association between HPV16 E6 antibody positivity and risk of anogenital cancers, including incident cervical, anal, penile, vulvar, and vaginal cancers, within the European Prospective Investigation Into Cancer and Nutrition EPIC study. The EPIC cohort was designed to investigate the relationship between nutritional and lifestyle factors and incidence of cancer and other chronic diseases.