Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation.
With this, the main obstacle is the limited exogenous uptake by the central nervous system CNS , making creatine only effective over a long-term diet of weeks.
Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels. Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate 0.
These outcomes suggest that a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration. The modern lifestyle and work pressure favor sleep deprivation SD , leading to more accidents, reduced performance, and chronic diseases.
To diminish these negative consequences, psychoactive substances such as caffeine gained immense popularity in recent decades. The sports community appreciates creatine in an ergogenic sense, to enhance physical peak performance.
