Official websites use. Share sensitive information only on official, secure websites. Correspondence: ana. This study aimed to investigate the specific role of nitric oxide NO in micro- and macrovascular response to a 7-day high-salt HS diet, specifically by measuring skin microvascular local thermal hyperemia and the flow-mediated dilation of the brachial artery, as well as serum NO and three NO synthase enzyme NOS isoform concentrations in healthy individuals. It also aimed to examine the concept of non-osmotic sodium storage in the skin following the HS diet by measuring body fluid status and systemic hemodynamic responses, as well as serum vascular endothelial growth factor C VEGF-C concentration.
Forty-six young, healthy individuals completed a 7-day low-salt diet, followed by a 7-day HS diet protocol. These results indicate that the 7-day HS-diet induces systemic impairment of NO-mediated endothelial vasodilation, while dissociation in the eNOS and nNOS response indicates complex adaptation of main NO-generating enzyme isoforms to HS intake in healthy individuals.
Our results failed to support the concept of non-osmotic sodium storage. Keywords: high-salt diet, endothelium, nitric oxide, nitric oxide synthase, vascular endothelial growth, microcirculation, macrocirculation. One of the main reasons for the high prevalence and poor AH control is the excessive intake of table salt, which in Croatia amounts to more than 11 g per day average This data was the basis for the development of the Strategic Plan for Reduction of Salt Intake in Croatia, aiming to reduce daily salt intake to 9.
Available data from show that average daily salt intake has decreased by 1. Alongside the clear association between high-salt HS intake and the development and progression of AH, some evidence indicates that increased salt intake affects vascular and endothelial function, even in the absence of changes in arterial blood pressure ABP [ 2 , 5 , 6 ] or body composition fluid changes in healthy individuals [ 7 , 8 , 9 , 10 ].
(mh=5OhVLaUO1RM1gmpR)6.jpg "Model Hooker in Osijek")
Endothelial dysfunction ED is a precursor and the earliest observable outcome of cardiovascular diseases CVDs , characterized by inappropriate activation of the endothelium [ 5 , 11 ]. ED has been demonstrated at macro- and microcirculatory level. Excessive salt intake may impair endothelial vascular function at both micro- and macrocirculation levels, potentially by suppression of the renin-angiotensin system RAS activity, an increased level of oxidative stress, and the activation of the endothelium, resulting in endothelialβleukocyte interaction and modulation of the inflammatory response, in otherwise healthy individuals [ 19 ].
