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To browse Academia. Levodopa-carbidopa intestinal gel LCIG infusion has demonstrated to improve motor fluctuations. Adverse events AE and their management, clinical motor, and nonmotor aspects were assessed up to 10 years.
Thirty-seven patients were treated with LGIC; in three subsets of patients, specific batteries of tests were used to assess cognitive and behavior assessment for 6 months, quality of sleep for 6 months, and quality of life and caregiver burden for 1 year. There was a high number of AE, but manageable, most of mild and moderate severity. All patients experienced significant improvement in motor fluctuations with a reduction in mean daily off time of 4.
Diskynesias remained stables in 28 patients Background: Parkinson's disease PD is the second most common progressive neurodegenerative disease. In the advanced stages, the continuous delivery of levodopa LD as levodopa-carbidopa intestinal gel LCIG has demonstrated significant improvement of motor and nonmotor complications and improvement of the patients' quality of life QoL.
Despite the growing global experience with this treatment, anumber of unsolved practical issues remain, and currently, the data on the reasons that can lead to the discontinuation of LCIG are scarce.
Objective: In the present study, we aimed to analyze the causes that led to the discontinuation of LCIG therapy. Methods: In this retrospective study, after 10 years of experience with LCIG as a therapeutic option in advanced PD, we analyzed the data of all dropout cases among the patients that initiated LCIG therapy in two Romanian centers.